ANALOGUES OF ACETYL CHYMOTRYPSIN

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Analogues of acetyl chymotrypsin.

Previous papers (1, 2) have reported the acylation of chymotrypsin with several nitrophenyl acetates. It was of obvious interest to test the behavior of nitrophenyl esters of other acids in the same connection. It now appears that chymotrypsin may be acylated by a number of acids differing considerably from acetic acid in structure. Beneoyl and salicyl chymotrypsins were prepared and found to r...

متن کامل

Acetyl chymotrypsin and its reaction with ethanol.

A short report has recently been made (1) concerning the preparation of an acetyl derivative of chymotrypsin containing a single acetyl group of relatively high reactivity. The reaction, which may be carried out by any of several nitrophenyl acetates, begins with a rapid initial liberation of the free nitrophenol in practically mole for mole proportions to the total chymotrypsin present. Therea...

متن کامل

The hydrolysis of N-benzoyl-DL-tyrosylglycinamide, N-acetyl-L-tyrosylglycinamide, and N-acetyl-DL-tyrosylglycinamide by chymotrypsin.

Contrary to the report of Bergmann and Fruton (1) the L peptide present in aqueous solutions of N-benzoyl-DL-tyrosylglycinamide, prepared by two independent methods, is rapidly hydrolyzed by crystalline chymotrypsin. At 40” and pH 7.8 in a 0.00344 M solution’ of the DL mixture the L component is hydrolyzed as rapidly as in a 0.00172 M solution of the L peptide (Table I). Because of the relative...

متن کامل

Chymotrypsin substrate analogues inhibit endocytosis of insulin and insulin receptors in adipocytes

To explore the possible role of proteolytic step(s) in receptor-mediated endocytosis of insulin, the effects of inhibitors of various classes of proteases on the internalization process were studied in isolated rat adipocytes. Intracellular accumulation of receptor-bound 125I-insulin at 37 degrees C was quantitated after rapidly dissociating surface-bound insulin with an acidic buffer (pH 3.0)....

متن کامل

The carcinogenic activities of certain analogues of 2-acetyl-aminofluorene in the rat.

a carcinogen originally discovered by Wilson, DeEds, and Cox (28), has been shown by these and many other investigators to be a highly active carcinogen that attacks nu merous sites in the rat and mouse. In addition, the parent hydrocarbon, fluorene, and several of its other derivatives have been tested for carcinogenic activity in the rat. Fluorene and its oxidation product, fluorenone, are in...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1957

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)70753-9